Dr. Alvar Gossert
Alvar Gossert has been in charge of the biomolecular NMR spectroscopy platform since 2017. At the platform we maintain a state-of-the-art research infrastructure, engange in scientific collaborations and teach coursers in biophysics and NMR. We also conduct our own research program focussing on drug discovery, in particular on GPCR signalling. We develop strategies for producing these difficult proteins in eukaryotic cell culture and develop NMR methods for studying their interactions at atomic resolution.
Curriculum Vitae
Alvar Gossert studied biochemistry at ETH Zürich, where he earned his PhD in 2006 under supervision of Prof. Kurt Wüthrich. He then moved to industry for a Postdoc in the structural biophysics group at Novartis Pharma AG in Basel. After nearly 10 years in drug discovery research, where he took different roles as laboratory head in protein production and NMR spectroscopy, he moved back to ETH Zürich where he became the head of the NMR platform of the department of biology.
2023
19F NMR in Drug Discovery : Past, Present and Future
Universität Münster GDCh Lecture (2023), Münster DE
2022
Advances in the Characterisation of Large Human Proteins by NMR Spectroscopy
GDCh Fachgruppe Magnetresonanz (2021), Karlsruhe DE
A Pipeline for Accelerating Drug Discovery
Experimental NMR conference - ENC (2022), Orlando FL USA
2021
Tackling GPCRs by NMR
Technische Universität München (2021), Garching DE (invited)
NMR in Drug Discovery
GDCh Fachgruppe Magnetresonanz (2021), virtual (invited tutorial lecture)
Screening and Ranking of Ligands by Fluorine NMR
NMR Winter Retreat of Protein-RNA Interactions (2021) Parpan CH
2020
NMR tools for studying large (>100 kDa) protonated proteins produced in human cells
Swiss NMR Symposium (2020) Geneva CH
Isotope labeling in mammalian cells on a shoestring
NMR Winter Retreat of Protein-RNA Interactions (2020) Parpan CH
2019
Studying protein-ligand interactions by NMR
University of Basel (2019) Basel CH (invited)
NMR tools for identification, validation and structural characterization of molecular interactions
Royal Society of Chemistry NMR Discussion Group (2019) Leeds UK (invited)
NMR studies of proteins produced in eukaryotic cells – challenges in expression and NMR spectroscopy
Advances in Isotope Labeling Meeting - AILM (2019) Grenoble FR (invited, including teaching in associated student course)
Producing protein for NMR studies in eukaryotic cells
UniZH (2019) Zürich CH
NMR tools for studying large, protonated membrane protein complexes produced in mammalian cells
NMR Winter Retreat of Protein-RNA Interactions (2019) Parpan CH
2018
New NMR tools for drug discovery: from screening to structure determination
iNEXT meeting (2018) Budapest HU (invited)
New NMR tools for drug discovery: from screening to structure determination
GDCh Fachgruppe Magnetresonanz (2018) Leipzig DE (invited)
A survey of best practices in NMR fragment screening
19F NMR Fragment Discovery Workshop (2018) Zürich CH (Organizer)
Structural biology in drug discovery – an NMR perspective
BSM retreat - Biomolecular structure and mechanism PhD program (2018) Morschach CH (invited)
Structure-based drug design by NMR
Swiss NMR Symposium (2018) Zürich CH
Structure-based drug design by NMR
NMR Winter Retreat of Protein-RNA Interactions (2018) Parpan CH
2017
New NMR tools for drug discovery: from validation to structure determination
Protein structure determination in industry - PSDI (2017) Cambridge UK (invited tutorial lecture)
Isotope labelling in eukaryotic cells for studying molecular interactions by NMR
IGBMC (2017) Strasbourg FR (invited)
New NMR tools for drug discovery: from validation to structure determination
Novalix (2017) Strasbourg FR (invited)
Structure-based drug design by NMR
Experimental NMR conference - ENC (2017) Asilomar US (invited)
Auto-inducing media for high-throughput protein production in structural biology
Advances in Isotope Labeling Meeting - AILM (2017) Grenoble FR (invited)
NMR in drug discovery
Modern analytical Methods in Structure Biology and Infection Research (2017) Hamburg DE (invited)
2016
Of ligands and proteins: Novel NMR techniques in drug discovery
ETH Zürich (2016) Zürich CH
Towards serial structure determination of protein-ligand complexes
Biozentrum (2016) Basel CH
2015
Affordable uniform isotope labeling with 2H, 13C and 15N in insect cells
Advances in Isotope Labeling Meeting - AILM (2015) Grenoble FR (invited)
Validation of protein-ligand interactions: A formalized assessment of biophysical methods and new avenues for NMR
RegioMeeting structural biology (2015), Engelberg CH (invited)
2014
Enzymes as tools for isotope labeling: Auto-inducing media for E.coli and methionine labeling in mammalian cells
EUROMAR (2014) Zürich CH
Concatenated NMR experiments for detection of protein ligand interactions in one scan: Avenues for DNP?
EPFL (2014) Lausanne CH
Advances in isotope labeling: Auto-inducing media for E.coli and methionine labeling in mammalian cells
Swiss NMR Symposium (2014) Basel CH
2013
Wide bandwidth TOCSY experiments for aromatic side chain assignment and more…
Experimental NMR conference - ENC (2013) Asilomar US
Self-cleaning fermenters and auto-inducing media for high-throughput parallel expression in 1–5 L scale
BioProduction (2013) Dublin IE (invited)
Life as a structural biologist in industrial drug discovery: Examples from NMR
BSM retreat - Biomolecular structure and mechanism PhD program (2013) Baar CH (invited)
2012 and earlier
Wide bandwidth TOCSY experiments
Swiss NMR Symposium (2012) Geneva CH
Self-cleaning and self-sterilizing fermenters for high-throughput expression of proteins
PEPTalk (2012) San Diego US (invited)
High-power TOCSY experiments and isotope labeling in insect cells
Scripps Research Institute (2012) La Jolla US
NMR-based drug discovery
Texas A&M University (2012) College Station US
Efficient detection and characterization of protein-ligand interactions in H2O
SMASH - Small Molecules Are Still Hot (2009) Chamonix FR (invited)
3’end caps for RNAi agents for use in RNA interference
J.L. Baryza, M.J.J. Blommers, C. Fernández, E. Geno, A.D. Gossert, P. Greenidge, D. Huesken, J. Hunziker, F.J.C. Natt, A. Patnaik (2015).
Patent WO 2015051045 A3
Novel formats for organic compounds for use in RNA interference
J.L. Baryza, M.J.J. Blommers, C. Fernández, E. Geno, A.D. Gossert, P. Greenidge, D. Huesken, J. Hunziker, F.J.C. Natt, A. Patnaik (2015).
Patent WO 2015051044 A2
Organic compositions to treat hepcidin-related diseases
J.L. Baryza, M.J.J. Blommers, T. Borland, C. Fernández, T. Gebuhr, E. Geno, A.D. Gossert, D. Huesken, J. Hunziker (2015).
Patent WO 2015051135 A3
Organic compounds to treat hepatitis B virus
J.L. Baryza, M.J.J. Blommers, C. Fernández, E. Geno, A.D. Gossert, P. Greenidge, D. Huesken, J. Hunziker, F.J.C. Natt, A. Patnaik (2015).
Patent WO 2015050871 A3