NMR drug screening and hybrid structure determination.
Modular Oxime formation: collaboration with J. Piel group published
Benzolactone enamides, a number of which incorporate a methylated oxime moiety, are produced by a range of organisms, and constitute a family of cytotoxic natural products. Here, we determine how this capped oxime group is installed during assembly of the model polyketide lobatamide by a modular trans-AT polyketide synthase and provide molecular insight into the responsible mono-oxygenase domain by X-ray crystallography.
Fragment screening by NMR: collaboration with F. Allain group published
Screening by NMR in combination with a novel hybrid structure determination approach has been used assess the drugability to of the nucleocapsid N-protein of SARS-CoV-2.